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Endocrine Abstracts

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ea0056p784 | Pituitary - Basic | ECE2018

CGH array analysis of pituitary tumors revealed a highly-disrupted genome

Lasolle Helene , Elsensohn Mad-Helenie , Alix Eudeline , Bonnefille Clement , Michel Jessica , Bardel Claire , Roy Pascal , Sanlaville Damien , Raverot Gerald

Introduction: Genetic of pituitary tumors (PT) is incompletely understood. The aim of this study was to search for somatic copy number variations (CNV) in pituitary tumors and evaluate their prognostic impact on tumor recurrence.Methods: CGH array analysis (Agilent SurePrint G3 Human CGH+SNP Microarray 4×180 K) was performed on 196 fresh-frozen PT (67 gonadotroph, 31 corticotroph, 38 prolactinomas, 60 somatotroph). PT were classified according to th...
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ea0070aep617 | Pituitary and Neuroendocrinology | ECE2020

SST5 expression and USP8 mutation in functioning and silent corticotroph pituitary tumors

Castellnou Solene , Vasiljevic Alexandre , Lapras Veronique , Raverot Véronique , Alix Eudeline , Borson-Chazot Francoise , Jouanneau Emmanuel , Raverot Gerald , Hélène Lasolle

Context: Somatostatin receptor type 5 (SST5) is inconsistently expressed by corticotroph tumors, with higher expression found in corticotropinomas having ubiquitin-specific protease 8 (USP8) mutations.Aims: To study the correlation between characteristics of corticotropinomasand SST5 expression/USP8 mutation status; to describe the response to pasireotide in 5 patients.Design: Retrospective cohort study.Metho...
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Published by BioScientifica

Endocrine Abstracts
ISSN 1470-3947 (print) | ISSN 1479-6848 (online)
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